Gene information
Official symbol TNFSF11
Official full name TNF superfamily member 11
Gene type protein-coding gene
Chromosome13q14
Alias symbolTRANCE; RANKL; OPGL; ODF; CD254
Gene familyCD molecules; Tumor necrosis factor superfamily
Resources
Entrez Gene 8600
HGNC HGNC:11926
Ensembl ENSG00000120659
Vega OTTHUMG00000016807
UCSC uc001uyu.3
GO terms: 118 records
GO Description Category LogP Number of genes Detail
GO:0001501 skeletal system development GO Biological Processes -17.2073293 69 More
GO:0001503 ossification GO Biological Processes -16.3087139 28 More
GO:0001894 tissue homeostasis GO Biological Processes -10.3152206 20 More
GO:0001934 positive regulation of protein phosphorylation GO Biological Processes -52.8272623 84 More
GO:0002520 immune system development GO Biological Processes -15.2957169 80 More
GO:0002521 leukocyte differentiation GO Biological Processes -12.4650129 27 More
GO:0002675 positive regulation of acute inflammatory response GO Biological Processes -10.8573789 13 More
GO:0002694 regulation of leukocyte activation GO Biological Processes -32.0887020 60 More
GO:0002696 positive regulation of leukocyte activation GO Biological Processes -27.9249645 47 More
GO:0002761 regulation of myeloid leukocyte differentiation GO Biological Processes -12.4818724 17 More
GO:0002763 positive regulation of myeloid leukocyte differentiation GO Biological Processes -8.56410954 10 More
GO:0002793 positive regulation of peptide secretion GO Biological Processes -7.26567394 18 More
GO:0005125 cytokine activity GO Molecular Functions -54.7097150 57 More
GO:0005126 cytokine receptor binding GO Molecular Functions -41.4908940 50 More
GO:0005164 tumor necrosis factor receptor binding GO Molecular Functions -5.56986570 6 More
GO:0006935 chemotaxis GO Biological Processes -33.1726887 55 More
GO:0008283 cell population proliferation GO Biological Processes -17.2298624 68 More
GO:0010720 positive regulation of cell development GO Biological Processes -17.713649 52 More
GO:0019221 cytokine-mediated signaling pathway GO Biological Processes -27.5840932 43 More
GO:0019722 calcium-mediated signaling GO Biological Processes -11.6647584 29 More
GO:0019932 second-messenger-mediated signaling GO Biological Processes -19.1717114 46 More
GO:0022407 regulation of cell-cell adhesion GO Biological Processes -32.4337382 53 More
GO:0022409 positive regulation of cell-cell adhesion GO Biological Processes -25.7751074 39 More
GO:0030097 hemopoiesis GO Biological Processes -14.1443585 71 More
GO:0030155 regulation of cell adhesion GO Biological Processes -41.8400792 131 More
GO:0030316 osteoclast differentiation GO Biological Processes -2.15842877 6 More
GO:0030545 signaling receptor regulator activity GO Molecular Functions -87.4728446 102 More
GO:0030546 signaling receptor activator activity GO Molecular Functions -90.4065983 101 More
GO:0030595 leukocyte chemotaxis GO Biological Processes -30.6401488 33 More
GO:0030879 mammary gland development GO Biological Processes -8.79064244 23 More
GO:0031347 regulation of defense response GO Biological Processes -64.5971043 148 More
GO:0031349 positive regulation of defense response GO Biological Processes -32.1301903 71 More
GO:0032103 positive regulation of response to external stimulus GO Biological Processes -58.7273809 118 More
GO:0032368 regulation of lipid transport GO Biological Processes -34.5766289 54 More
GO:0032813 tumor necrosis factor receptor superfamily binding GO Molecular Functions -5.47819787 7 More
GO:0032890 regulation of organic acid transport GO Biological Processes -14.1608908 23 More
GO:0032892 positive regulation of organic acid transport GO Biological Processes -8.61037442 14 More
GO:0033209 tumor necrosis factor-mediated signaling pathway GO Biological Processes -6.18341292 8 More
GO:0033674 positive regulation of kinase activity GO Biological Processes -29.8538991 87 More
GO:0034103 regulation of tissue remodeling GO Biological Processes -21.5631413 32 More
GO:0034110 regulation of homotypic cell-cell adhesion GO Biological Processes -6.42713539 7 More
GO:0034612 response to tumor necrosis factor GO Biological Processes -24.4651326 32 More
GO:0042330 taxis GO Biological Processes -33.0828571 55 More
GO:0042476 odontogenesis GO Biological Processes -9.69427751 24 More
GO:0043269 regulation of ion transport GO Biological Processes -36.9814668 116 More
GO:0043405 regulation of MAP kinase activity GO Biological Processes -18.9267681 42 More
GO:0043406 positive regulation of MAP kinase activity GO Biological Processes -13.8261343 18 More
GO:0043408 regulation of MAPK cascade GO Biological Processes -57.2547066 142 More
GO:0043410 positive regulation of MAPK cascade GO Biological Processes -49.4744054 112 More
GO:0043549 regulation of kinase activity GO Biological Processes -36.8507249 123 More
GO:0044070 regulation of anion transport GO Biological Processes -12.6410846 24 More
GO:0045124 regulation of bone resorption GO Biological Processes -6.02130395 7 More
GO:0045453 bone resorption GO Biological Processes -4.37707433 7 More
GO:0045637 regulation of myeloid cell differentiation GO Biological Processes -9.39364926 18 More
GO:0045639 positive regulation of myeloid cell differentiation GO Biological Processes -7.07849207 11 More
GO:0045785 positive regulation of cell adhesion GO Biological Processes -29.6368249 50 More
GO:0045859 regulation of protein kinase activity GO Biological Processes -34.3615088 109 More
GO:0045860 positive regulation of protein kinase activity GO Biological Processes -29.3929160 47 More
GO:0046328 regulation of JNK cascade GO Biological Processes -6.26985667 21 More
GO:0046849 bone remodeling GO Biological Processes -4.21089449 9 More
GO:0046850 regulation of bone remodeling GO Biological Processes -7.11509809 13 More
GO:0046887 positive regulation of hormone secretion GO Biological Processes -9.61661717 24 More
GO:0048018 receptor ligand activity GO Molecular Functions -91.0736151 101 More
GO:0048534 hematopoietic or lymphoid organ development GO Biological Processes -16.4041704 79 More
GO:0048732 gland development GO Biological Processes -26.3979320 74 More
GO:0048771 tissue remodeling GO Biological Processes -15.8777137 28 More
GO:0048871 multicellular organismal homeostasis GO Biological Processes -14.5562171 53 More
GO:0050727 regulation of inflammatory response GO Biological Processes -68.5964592 121 More
GO:0050729 positive regulation of inflammatory response GO Biological Processes -38.1621935 57 More
GO:0050801 ion homeostasis GO Biological Processes -12.0812968 60 More
GO:0050863 regulation of T cell activation GO Biological Processes -20.3209154 36 More
GO:0050865 regulation of cell activation GO Biological Processes -40.6877761 71 More
GO:0050867 positive regulation of cell activation GO Biological Processes -31.2431659 51 More
GO:0050870 positive regulation of T cell activation GO Biological Processes -17.6497748 28 More
GO:0050900 leukocyte migration GO Biological Processes -39.9164759 46 More
GO:0051046 regulation of secretion GO Biological Processes -54.0079540 130 More
GO:0051047 positive regulation of secretion GO Biological Processes -32.2282376 71 More
GO:0051090 regulation of DNA-binding transcription factor activity GO Biological Processes -25.8933515 78 More
GO:0051091 positive regulation of DNA-binding transcription factor activity GO Biological Processes -17.7436786 49 More
GO:0051092 positive regulation of NF-kappaB transcription factor activity GO Biological Processes -14.8614421 21 More
GO:0051249 regulation of lymphocyte activation GO Biological Processes -22.6120519 46 More
GO:0051251 positive regulation of lymphocyte activation GO Biological Processes -20.2181987 37 More
GO:0051347 positive regulation of transferase activity GO Biological Processes -26.6059528 90 More
GO:0051896 regulation of protein kinase B signaling GO Biological Processes -30.5149255 55 More
GO:0051897 positive regulation of protein kinase B signaling GO Biological Processes -23.7578366 39 More
GO:0055065 metal ion homeostasis GO Biological Processes -12.9426258 29 More
GO:0055074 calcium ion homeostasis GO Biological Processes -10.3600555 19 More
GO:0055080 cation homeostasis GO Biological Processes -11.5718912 30 More
GO:0060249 anatomical structure homeostasis GO Biological Processes -12.3640817 24 More
GO:0060284 regulation of cell development GO Biological Processes -22.9455891 78 More
GO:0060326 cell chemotaxis GO Biological Processes -35.3882493 41 More
GO:0060348 bone development GO Biological Processes -12.2474877 36 More
GO:0070372 regulation of ERK1 and ERK2 cascade GO Biological Processes -38.4320790 79 More
GO:0070374 positive regulation of ERK1 and ERK2 cascade GO Biological Processes -34.9831828 64 More
GO:0070661 leukocyte proliferation GO Biological Processes -8.25401122 12 More
GO:0071345 cellular response to cytokine stimulus GO Biological Processes -39.647808 70 More
GO:0071356 cellular response to tumor necrosis factor GO Biological Processes -22.5666334 29 More
GO:0071674 mononuclear cell migration GO Biological Processes -16.6998600 20 More
GO:0071900 regulation of protein serine/threonine kinase activity GO Biological Processes -19.5794055 63 More
GO:0071902 positive regulation of protein serine/threonine kinase activity GO Biological Processes -13.5008002 23 More
GO:0072507 divalent inorganic cation homeostasis GO Biological Processes -10.6286093 21 More
GO:0080135 regulation of cellular response to stress GO Biological Processes -19.0128542 89 More
GO:0090277 positive regulation of peptide hormone secretion GO Biological Processes -6.66447400 17 More
GO:0097529 myeloid leukocyte migration GO Biological Processes -25.8454617 28 More
GO:0098771 inorganic ion homeostasis GO Biological Processes -12.1048319 31 More
GO:1902105 regulation of leukocyte differentiation GO Biological Processes -18.8286876 32 More
GO:1902107 positive regulation of leukocyte differentiation GO Biological Processes -14.6775052 22 More
GO:1903037 regulation of leukocyte cell-cell adhesion GO Biological Processes -23.2079690 66 More
GO:1903039 positive regulation of leukocyte cell-cell adhesion GO Biological Processes -20.7355312 32 More
GO:1903530 regulation of secretion by cell GO Biological Processes -45.6472055 114 More
GO:1903532 positive regulation of secretion by cell GO Biological Processes -27.9542102 63 More
GO:1903706 regulation of hemopoiesis GO Biological Processes -16.2759166 33 More
GO:1903708 positive regulation of hemopoiesis GO Biological Processes -14.6775052 22 More
GO:1903793 positive regulation of anion transport GO Biological Processes -7.11509809 13 More
GO:1905952 regulation of lipid localization GO Biological Processes -40.6150331 64 More
GO:1990823 response to leukemia inhibitory factor GO Biological Processes -3.54378087 13 More
GO:1990830 cellular response to leukemia inhibitory factor GO Biological Processes -3.58748665 13 More
GO:2000191 regulation of fatty acid transport GO Biological Processes -10.7141263 14 More
KEGG pathways: 8 records
KEGG Description Category LogP Number of genes Detail
hsa04060 Cytokine-cytokine receptor interaction KEGG Pathway -61.0014447 66 More
hsa04064 NF-kappa B signaling pathway KEGG Pathway -10.0294934 14 More
hsa04380 Osteoclast differentiation KEGG Pathway -7.05199617 21 More
hsa04917 Prolactin signaling pathway KEGG Pathway -3.17844000 10 More
hsa04928 Parathyroid hormone synthesis, secretion and action KEGG Pathway -3.30201840 7 More
hsa05207 Chemical carcinogenesis - receptor activation KEGG Pathway -7.05448873 28 More
hsa05224 Breast cancer KEGG Pathway -6.01672252 21 More
hsa05323 Rheumatoid arthritis KEGG Pathway -22.3868189 23 More
Drug-Gene interaction
view
Related drugs: 4 records
Related studies: 2 records
Molecular factor Omics type Application Objective MI type Reference
tumor necrosis factor ligand superfamily member 11 proteomics acute ST elevation myocardial infarction[diagnosis] acute ST elevation myocardial infarction Crisafulli A et al. Clin Sci (Lond). 2005
tumor necrosis factor ligand superfamily member 11 proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Halapas A et al. Clin Chem Lab Med. 2008
All rights reserved: Soochow University Center for Systems Biology